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Tocris Bioscience™ GSK 2837808A
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Artikelnummer. 18767058
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18767058 10mg
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Artikelnummer. 18767058 Leverandør Tocris Bioscience™ Leverandørnr. 5189/10

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Beskrivelse

Potent and selective LDHA inhibitor

GSK 2837808A is a potent and selective lactate dehydrogenase A and B (LDHA and LDHB) inhibitor (IC50 values are 2.6 and 43 nM for LDHA and LDHB respectively). Inhibits lactate production in selected cancer cell lines. Reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells. Inhibits proliferation and induces apoptosis in Snu398 cells. Inhibits transcription of histone 2B (H2B) gene in HCT116 and NCM460 cells. Cell permeable.
TRUSTED_SUSTAINABILITY

Tekniske data

CAS 1445879-21-9
Mængde 10 mg
Molekylær formel 3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)benzoic acid
Produkttype GSK 2837808A
Renhed 98%
Molekylvægt (g/mol) M.W. (Observed): 649.62
Inhibitorer GSK 2837808A

For Research Use Only

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