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Tocris Bioscience™ GS 441524
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Artikelnummer. 18766916
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Artikelnummer. Mængde
18766916 50 mg
18717576 10 mg
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Artikelnummer. 18766916 Leverandør Tocris Bioscience™ Leverandørnr. 7227/50

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Beskrivelse

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide

GS 441524 is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and broad spectrum antiviral nucleotide; active metabolite of Remdesivir (Cat. No. 7226). Competes with natural nucleoside triphosphates, blocking viral RNA synthesis. Exhibits antiviral activity against viruses from Coronaviridae family including SARS-CoV-2 in vitro, and SARS-CoV and feline infectious peritonitis virus (FIPV) in vitro and in vivo. Inhibits SARS-CoV and MERS-CoV- infected HAE cultures (EC50 values are 0.18 and 0.86 μM, respectively) and inhibits murine hepatitis virus (MHV) (EC50 = 1.1 μM).
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (2 R,3 R,4 S,5 R)-2-(4-Aminopyrrolo[2,1-f][1,2,4 ]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
CAS 1191237-69-0
Mængde 50 mg
Mål RNA/DNA Polymerase Inhibitors
Molekylær formel C12H13N5O4
Renhed 0.98
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