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Tocris Bioscience™ GNF 7
Ras signaling inhibitor; inhibits Ack1 and GCK
Brand: Tocris Bioscience™ 5607/10
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Beskrivelse
GNF 7 is a potent Bcr-Abl inhibitor (IC50 values are 61 and 133 nM for T315I and wild-type Bcr-Abl, respectively), inhibiting a range of clinically relevant Bcr-Abl mutants such as T315I, G250E, E255V, F317L and M351T. GNF 7 is also a Ras signaling inhibitor as well as inhibiting Ack1 and germinal center kinase (GCK). GNF 7 induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations, and shows growth inhibitory activity in human colon cancer cells. It prolongs survival in a leukemia cell xenotransplantation model in mice and is orally bioavailable.Tekniske data
| Ras GTPase Inhibitors | |
| 839706-07-9 | |
| 10 mg |
Produkttitel
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