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Tocris Bioscience™ GNF 7
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Artikelnummer. 18743979
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Mængde:
10 mg
50 mg
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Artikelnummer. Mængde
18743979 10 mg
18789927 50 mg
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Artikelnummer. 18743979 Leverandør Tocris Bioscience™ Leverandørnr. 5607/10

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Beskrivelse

Ras signaling inhibitor; inhibits Ack1 and GCK

GNF 7 is a potent Bcr-Abl inhibitor (IC50 values are 61 and 133 nM for T315I and wild-type Bcr-Abl, respectively), inhibiting a range of clinically relevant Bcr-Abl mutants such as T315I, G250E, E255V, F317L and M351T. GNF 7 is also a Ras signaling inhibitor as well as inhibiting Ack1 and germinal center kinase (GCK). GNF 7 induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations, and shows growth inhibitory activity in human colon cancer cells. It prolongs survival in a leukemia cell xenotransplantation model in mice and is orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale Ras GTPase Inhibitors
CAS 839706-07-9
Mængde 10 mg
Mål Small G Protein Inhibitors
Molekylær formel C28H24F3N7O2
Formel vægt 547.53
Renhed >98%
Produkttitel
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