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STEMCELL Technologies Genistein

Artikelnummer. 17110012
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Mængde:
100 mg
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Artikelnummer. Mængde
17110012 100 mg
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Artikelnummer. 17110012 Leverandør STEMCELL Technologies Leverandørnr. 72002

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Beskrivelse

NF-kB, AMPK, and tyrosine kinase pathway inhibitor; Inhibits tyrosine kinase, topoisomerase II and activates PPARγ

  • Genistein is a phytoestrogen that exhibits a wide range of biological effects
  • It acts by competing for the ATP-binding site of tyrosine kinases but does not inhibit the activity of serine- and threonine-specific kinases such as cAMP-dependent protein kinase, protein kinase C, and phosphorylase kinase (Akiyama et al.) Genistein binds to and activates peroxisome proliferator-activated receptor-gamma (PPARγ) and estrogen receptors, leading to a decrease in osteogenesis and an increase in adipogenesis (Dang et al.) Genistein also binds and activates the seven-transmembrane estrogen receptor GPR30 to activate alternative estrogen signaling pathways (Thomas & Dong)
  • Inhibits adipocyte differentiation in 3T3-L1 cell culture (Hwang et al.)
  • Control of osteoblast and adipocyte cell fates in mouse bone marrow cells (Dang et al.)
  • Inhibits growth of leukemia, lymphoma, neuroblastoma, gastric, breast, and prostate cancer cells (Sarkar & Li)

Tekniske data

CAS 446-72-0
Mængde 100 mg
Molekylær formel C15H10O5
Renhed ≥98%
Produkttitel
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