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Thermo Scientific™ GeneBLAzer™ MC5R-CRE-bla CHO-K1 Cells

GeneBLAzer™ MC5R-CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 5 (MC5R) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line.

Brand:  Thermo Scientific™ K1740

Product Code. 10033833

  • 117600.00 DKK / Each

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Description

Description

GeneBLAzer™ MC5R-CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 5 (MC5R) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™ CRE-bla CHO-K1 cells (Cat. No. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.

The GeneBLAzer™ MC5R-CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of NPD-α MSH In addition, GeneBLAzer™ MC5R-CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

MC5R is expressed in skin, muscle, lung, liver, spleen, and adrenal tissue. MC5R is Gs-coupled and binds all of the melanocortin peptides and ACTH. A recent study suggests that MC5R is involved in fat storage in the sebocyte cells of the skin. Another study in mice links MC5R to aggressive behavior. Mice deficient in MC5R acted less aggressively when treated with alpha-MSH.

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GeneBLAzer MC5R CHO-K1 Cell-based Assay Version: 31 October 2010 File size: 259.8 kB
GeneBLAzer® MC5R CRE-bla CHO-K1 Cell Line Validation Packet Version: version 1.1 File size: 154.1 kB
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Lot Number Certificate Type Date Catalog Number
Lot Number37633 Certificate TypeCertificate of Analysis Date16/04/2017 Catalog NumberK1740
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Thermo Scientific™ GeneBLAzer™ MC5R-CRE-bla CHO-K1 Cells > 2 x 106 Cells

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