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  6. Geldanamycin, 98+%

Geldanamycin, 98+%

Artikelnummer. 15425649
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Artikelnummer. 15425649 Leverandør Thermo Scientific Alfa Aesar Leverandørnr. J63397.MD
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Beskrivelse

Benzoquinoid antibiotic that inhibits pp60src tyrosine kinase | CAS: 30562-34-6 | C29H40N2O9 | 560.644 g/mol

Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.

Notes
Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 30562-34-6
Molekylær formel C29H40N2O9
Molekylvægt (g/mol) 560.644
MDL nummer MFCD00274570
InChI nøgle QTQAWLPCGQOSGP-KDFVLELPSA-N
Synonym NSC 122750; U-29135
PubChem CID 133688416
IUPAC navn [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
SMIL CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC

Tekniske data

Kemisk navn eller materiale Geldanamycin
Type Geldanamycin
Fysisk form Powder
Farve Orange to Yellow
Mængde 250 mg
Opløselighedsinformation Soluble in dimethyl sulfoxide at 100mg/mL.
Formel vægt 560.64
Procent renhed ≥99%

RUO – Research Use Only

Produkttitel
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