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STEMCELL Technologies Geldanamycin

Artikelnummer. 17140312
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Mængde:
1 mg
5 mg
Pakningsstørrelse:
5mg
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17140312 1 mg -
17150312 5 mg 5mg
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Artikelnummer. 17140312 Leverandør STEMCELL Technologies Leverandørnr. 74032

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Beskrivelse

Inhibits Hsp90

  • Geldanamycin is a benzoquinone ansamycin antibiotic that selectively inhibits heat shock protein 90 (Hsp90) (Schulte et al.; Whitesell et al.) It inhibits the ATPase activity of Hsp90 by binding with high affinity to the N-terminal ATP-binding site (Kd = 1.2 μM; Roe et al.) Geldanamycin also binds to the glucose-regulated protein GRP94, an endoplasmic reticulum protein with homology to Hsp90
  • This interaction destabilizes its complex with p185-ERBB2 leading to degradation of ERBB2 protein, which is overexpressed in aggressive breast cancers (Chavany et al.; Castagnola et al.)
  • Inhibits growth of 60 human tumor cell lines (Supko et al.)
  • Regulates innate immune response as demonstrated by inhibition of inflammasome activity in a mouse gout model (Mayor et al.)
  • Inhibits replication of HSV-1 and HSV-2 (Li et al.)

Tekniske data

CAS 30562-34-6
Synonym NSC 122750
Mængde 1 mg
Molekylær formel C29H40N2O9
Renhed ≥98%
Produkttitel
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