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STEMCELL Technologies GDC-0941

Artikelnummer. 17120182
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Mængde:
10 mg
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17120182 10 mg
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Artikelnummer. 17120182 Leverandør STEMCELL Technologies Leverandørnr. 73152

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Beskrivelse

PI3K/AKT pathway inhibitor; Inhibits Class I PI3Ks

  • GDC-0941 is an inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)
  • It inhibits class I catalytic subunits of PI3K p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM, respectively, by binding near the ATP binding pocket (Folkes et al.; Berndt et al.) It shows selectivity against class II, III, and IV PI3K isoforms as well, but with lower efficacy; for example, it inhibits phosphatidylinositol-4-phosphate 3-kinase C2 domain subunit β (C2β, Class II) and mammalian target of rapamycin (mTOR, Class IV) in the high nanomolar range and most others in the micromolar range (Folkes et al.)
  • Inhibits proliferation of multiple cancer cell lines, such as U87MG (glioblastoma), PC3 (prostate) and MDA-MB-361 (breast) lines, in vitro and in mouse xenograft models (Folkes et al.; Raynaud et al.; O'Brien et al.)
  • Induces apoptosis and inhibits xenograft tumor growth in combination with a MAP/ERK kinase (MEK) inhibitor GDC-0973 (Hoeflich et al.)

Tekniske data

CAS 957054-30-7
Synonym GNE 0941; Pictilisib; Pictrelisib
Mængde 10 mg
Molekylær formel C23H27N7O3S2
Renhed ≥98%
Produkttitel
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