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Tocris Bioscience™ Galunisertib
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Artikelnummer. 18779136
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25 mg
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18779136 25 mg
18777976 5 mg
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Artikelnummer. 18779136 Leverandør Tocris Bioscience™ Leverandørnr. 6956/25

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Beskrivelse

ALK4 and ALK5 (TGFβRI) inhibitor

Galunisertib is an ALK4 and ALK5 (TGFβRI) inhibitor (IC50 values are 77.7 and 172 nM, respectively). Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGFβRII, ALK6 and ACVR2B. Inhibits TGFβ-induced SMAD phosphorylation in cancer cell lines in vitro and in vivo. Also reverses TGFβ-mediated suppression of T cell proliferation. Prevents TGFβ-mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo. Used as component of growth media for urothelial organoids. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
CAS 700874-72-2
Mængde 25 mg
Mål TGF-beta Receptor Inhibitors
Molekylær formel C22H19N5O
Formel vægt 369.43
Produkttype Inhibitor
Renhed 98%
Produkttitel
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