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Tocris Bioscience™ G-1

Artikelnummer. 18094882
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Mængde:
10 mg
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18094882 10 mg
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Artikelnummer. 18094882 Leverandør Tocris Bioscience™ Leverandørnr. 3577/10

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Descrizione

Potent and selective GPER agonist

G-1 is a potent and selective GPER agonist (Ki = 11 nM, EC50 = 2 nM); displays no activity at ERα and ERβ at concentrations up to 10 μM. Increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants (IC50 values are 0.7 and 1.6 nM respectively) in vitro. Blocks MCF-1 cell cycle progression at the G1 phase. Displays therapeutic effects in the mouse EAE model of multiple sclerosis. Also inhibits glutamate-induced autophagy and neuronal loss in cultured primary cortical neurons.
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Specifica

Kemisk navn eller materiale (±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]- ethanone
CAS 881639-98-1
Mængde 10 mg
Mål Estrogen and Related Receptor Agonists
Molekylær formel C21H18BrNO3
Renhed 98%
Titolo del prodotto
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