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Tocris Bioscience™ FM19G11
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Artikelnummer. 18729096
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Mængde:
5 mg
25 mg
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Artikelnummer. Mængde
18729096 25 mg
18726126 5 mg
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Artikelnummer. 18729096 Leverandør Tocris Bioscience™ Leverandørnr. 6653/25

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Beskrivelse

HIF α-subunit inhibitor

FM19G11 is a hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate
CAS 329932-55-0
Mængde 25 mg
Molekylær formel C23H17N3O8
Formel vægt 463.4
Renhed 98%
Produkttitel
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