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Invitrogen™ Human FLT1 (VEGFR1), GST Tag Recombinant Protein

Artikelnummer. 11573497
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Mængde:
10 μg
Pakningsstørrelse:
10µg
Artikelnummer. Mængde unitSize
11573497 10 μg 10µg
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Artikelnummer. 11573497

Brand: Invitrogen™ PV3666

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic

FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis. Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P17948
Koncentration See Label
Til brug med (applikation) Kinase Assay
Formulering 50 mM tris with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
Gen-id (Entrez) 2321
Molekylvægt (g/mol) 92.6 kDa
Navn Human FLT1 (VEGFR1), GST Tag
Mængde 10 μg
Regulatorisk status For research use only. Not for use in diagnostic procedures
Gene Alias AI323757; embryonic receptor kinase 2; Emrk2; FLT; FLT1; FLT-1; fms related tyrosine kinase 1; FMS-like tyrosine kinase 1; FMS-related tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FRT; i21; sFlt1; soluble VEGFR 1; sVEGFR 1; Tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; vascular permeability factor receptor; VEGF R1; VEGFR1; VEGFR-1
Fælles navn VEGF Receptor 1
KinaseFamily VEGF receptors
Protein længde 781-1338
Produkttype FLT1 (VEGFR1) Recombinant Human Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Protein tag GST-tag
Indhold og opbevaring -80°C, Avoid Freeze/Thaw Cycles
Udtrykssystem Insect cells
Protein familie Kinases and inhibitors
Form Liquid
Protein undertype Receptor tyrosine kinases
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