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STEMCELL Technologies FK506

Artikelnummer. 17180332
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17180332 10 mg
17190332 50 mg
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Artikelnummer. 17180332 Leverandør STEMCELL Technologies Leverandørnr. 74152

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Beskrivelse

Calcineurin/NFAT pathway inhibitor; Binds FKBP-12

  • FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.) It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.)
  • Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.)
  • In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.)
  • Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.)

Tekniske data

CAS 104987-11-3
Synonym Tacrolimus
Mængde 10 mg
Molekylær formel C44H69NO12
Renhed ≥99%
Produkttitel
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