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Tocris Bioscience™ FK 866
Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
Brand: Tocris Bioscience™ 8072/10
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Description
FK 866 is a non-competitive and high-affinity inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by Etoposide (Cat. No. 1226) and Cisplatin (Cat. No. 2251).
Specifications
| (2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide | |
| 10 mg | |
| C24H29N3O2 |
| 658084-64-1 | |
| NAMPT Inhibitors | |
| 98% |
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Product Title
Tocris Bioscience™ FK 866 > 10 mg
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