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Invitrogen™ Factor X/Xa Monoclonal Antibody (5051)
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Artikelnummer. 11529862
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Mængde:
100 μg
Pakningsstørrelse:
100µg
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11529862 100 μg 100µg
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Artikelnummer. 11529862 Leverandør Invitrogen™ Leverandørnr. MA143014

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Beskrivelse

Mouse Monoclonal Antibody

This antibody detects the heavy chain of bovine Factor X and Xa, BEGRck factor Xa. It will cross-react with human, rabbit, sheep, porcine and canine factor X. This antibody does not recognize murine Factor X via Western blot. Inhibitory properties: inhibitory in clotting assay (APTT and PT), partial calcium dependence. Dissociation Constant: Kd = 9X10^(-11)M. Purity >95% by SDS-PAGE.

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Factor X/Xa
Applikationer Affinity Purification, Inhibition Assays, Radioimmune Assays (RIA), Western Blot
Klassifikation Monoclonal
Klon 5051
Koncentration 8.4 mg/mL
Konjugeret Unconjugated
Formulering 50% water with 50% glycerol and no preservative
Gene F10
Genadgangsnr. O19045, P00742, P00743
Gene Alias Activated factor Xa heavy chain; blood coagulation factor X; Cf10; coagulation factor 10; coagulation factor X; coagulation factor X protein; F10; Factor X heavy chain; Factor X light chain; factor Xa; FX; FXA; prothrombinase; stuart factor; Stuart-Prower factor; Unknown (protein for IMAGE:8121240); unnamed protein product
Gensymboler F10
Værtsarter Mouse
Immunogen Purified bovine Factor X.
Oprensningsmetode SDS-PAGE
Mængde 100 μg
Regulatorisk status RUO
Primær eller sekundær Primary
Gen-id (Entrez) 100008647, 101118624, 2159, 280787, 476993, 733662
Målarter Human, Canine, Rabbit, Bovine, Sheep, Pig
Indhold og opbevaring -20°C, Avoid Freeze/Thaw Cycles
Produkttype Antibody
Form Liquid
Isotype IgG1
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