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STEMCELL Technologies EX527

Artikelnummer. 17180252
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Mængde:
10 mg
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Artikelnummer. Mængde
17180252 10 mg
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Denne vare kan ikke returneres. Se returpolicy
Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.
Artikelnummer. 17180252 Leverandør STEMCELL Technologies Leverandørnr. 73654

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Denne vare kan ikke returneres. Se returpolicy
Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.

Beskrivelse

Epigenetic modifier; Inhibits SIRT1 histone deacetylase

  • EX527 is a cell-permeable, selective inhibitor of mammalian sirtuin 1 (SIRT1; IC50 = 98 nM) over SIRT2 and SIRT3 and has no effect on other histone deacetylases (HDACs; Nayagam et al.) SIRT1 is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase with roles in energy metabolism and inflammation
  • Studies have shown that EX527 inhibits sirtuins by forming a trimeric sirtuin complex with an NAD+-derived coproduct (Gertz M et al.)
  • Increases the production of oligodendrocytes from differentiating neural stem cells and neural progenitor cells in vitro (Rafalski et al.)
  • Restores the microvascular response during the hypoinflammatory phase in a mouse model of sepsis, and enhances the systemic innate immune response (Vachharajani et al.)
  • Delays cyst growth in kidneys of PKD1 knockout mouse models (Zhou et al.)

Tekniske data

CAS 49843-98-3
Synonym Selisistat
Mængde 10 mg
Molekylær formel C13H13ClN2O
Renhed ≥98%
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