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Tocris Bioscience™ Ex 26
Potent and selective S1P1 receptor antagonist
Brand: Tocris Bioscience™ 5833/10
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Beskrivelse
Ex 26 is a potent and selective S1P1 receptor antagonist (IC50 = 0.93 nM). Exhibits > 3,000-fold selectivity for S1P1 over S1P2, S1P3, S1P4 and S1P5. Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P1 receptor expression. Reduces disease severity in mice with EAE. Increases IFN-α production in stimulated dendritic cells in vivo.Tekniske data
| 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid | |
| 50 mg | |
| Solid | |
| Bioactive Small Molecule |
| 144678-63-7 | |
| Soluble to 100mM in DMSO and to 100mM in ethanol | |
| White |
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