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  5. Tocris Bioscience™ Evofosfamide

Tocris Bioscience™ Evofosfamide

Artikelnummer. 18004052
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50 mg
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18004052 50 mg
18063902 10 mg
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Artikelnummer. 18004052 Leverandør Tocris Bioscience™ Leverandørnr. 7507/50

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Beskrivelse

Hypoxia-activated DNA alkylating agent prodrug

Evofosfamide is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM). Evofosfamide is stable under normoxic conditions but is activated by cellular reductases in hypoxic conditions (IC50 values are 5.1 μM and 0.019 μM, in NSCLC cells under normoxic and hypoxic conditions, respectively). Br-IPM acts as a DNA alkylating agent, inducing intrastrand and interstrand crosslinks. Evofosfamide inhibits NEPC PDX tumor growth by 84.5% in adeno-CRPC and NEPC patient-derived xenograft models. When combined with gemcitabine (Cat. No. 3259), Evofosfamide inhibits primary tumor growth by 96% and significantly extends the survival time in the MIA PaCa-2 human pancreatic cancer orthotopic xenograft model.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate
CAS 918633-87-1
Mængde 50 mg
Mål Apoptosis Inducer Compounds
Molekylær formel C9H16Br2N5O4P
Renhed 0.98
Produkttitel
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