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STEMCELL Technologies Everolimus

Artikelnummer. 17190172
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25 mg
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Artikelnummer. Mængde
17190172 25 mg
17180172 10 mg
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Artikelnummer. 17190172 Leverandør STEMCELL Technologies Leverandørnr. 73124

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Beskrivelse

mTOR pathway inhibitor; Inhibits FKBP-12

  • Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR)
  • It is a hydroxyethyl ether-substituted derivative of rapamycin with improved pharmacokinetic and pharmacodynamic properties
  • It inhibits both mTORC1 and mTORC2 complexes by binding to FK506-binding protein (FKBP-12), which then binds to mTOR, leading to complex destabilization and blocked kinase function (Zeng et al.; Lebwohl et al.; Sedrani et al.; Huang & Houghton)
  • Inhibits cell proliferation, metabolism, and angiogenesis in a variety of cancers using in vitro and in vivo models (Zhu et al.; Lane et al.; O'Reilly et al.; Lebwohl et al.)
  • Acts as an immunosuppressive agent in the context of organ transplantation (Lebwohl et al.; Wullschleger et al.)

Tekniske data

CAS 159351-69-6
Synonym RAD001; SDZ-RAD; Xience
Mængde 25 mg
Molekylær formel C53H83NO14
Renhed ≥95%
Produkttitel
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