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Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (A7L6), Alexa Fluor™ 594, Novus Biologicals™

Artikelnummer. 18191249 Shop alle Bio Techne produkter
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Mængde:
0.1 mL
Pakningsstørrelse:
0.1ml
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18191249 0.1 mL 0.1ml
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Artikelnummer. 18191249 Leverandør Novus Biologicals Leverandørnr. NBP247695AF594

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Beskrivelse

Rat Monoclonal Antibody

Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Monoclonal specifically detects Endorepellin/Perlecan/Heparan Sulfate Proteoglycan in Human, Mouse, Porcine, Bovine, Fish, Monkey samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.
TRUSTED_SUSTAINABILITY

Tekniske data

Antigen Endorepellin/Perlecan/Heparan Sulfate Proteoglycan
Applikationer Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Klassifikation Monoclonal
Klon A7L6
Konjugeret Alexa Fluor 594
Fortynding Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulering 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias basement membrane-specific heparan sulfate proteoglycan core protein, endorepellin (domain V region), heparan sulfate proteoglycan 2, HSPG, perlecan, perlecan proteoglycan, PLCSchwartz-Jampel syndrome 1 (chondrodystrophic myotonia), PRCAN, SJA, SJS, SJS1
Gensymboler HSPG2
Værtsarter Rat
Immunogen Murine EHS laminin preparation
Oprensningsmetode Protein A or G purified
Mængde 0.1 mL
Regulatorisk status RUO
Primær eller sekundær Primary
Testspecificitet This monoclonal antibody specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecans strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Målarter Human, Mouse, Pig, Fish, Monkey
Indhold og opbevaring Store at 4°C in the dark.
Isotype IgG2a κ
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