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  5. Tocris Bioscience™ Emricasan

Tocris Bioscience™ Emricasan

Artikelnummer. 18014902
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Mængde:
5 mg
25 mg
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Artikelnummer. Mængde
18014902 25 mg
18055742 5 mg
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Artikelnummer. 18014902 Leverandør Tocris Bioscience™ Leverandørnr. 7310/25

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Beskrivelse

Potent pan-caspase inhibitor

Emricasan is a potent caspase inhibitor (IC50 values are 0.3, 0.4, 2, 4, 6, 6 and 20 nM for caspase-9, -1, -3, -6, -7, -8, and -2, respectively). Emricasan is antiapoptotic by inhibiting caspase 8. It also preserves cell viability after infection with several strains of Zika. Emricasan promotes survival of pluripotent stem cells in culture when used in combination with Chroman-1 (Cat. No. 7163), trans-ISRIB (Cat. No. 5284) and Polyamine Supplement x1000 (lyophilized) (Cat. No. 7739), a combination known as CEPT. When used as part of the CEPT cocktail, Emricasan improves survival of differentiated cells following cryopreservation. The compound also reduces hepatic inflammation in an animal model of liver injury. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
CAS 254750-02-2
Mængde 25 mg
Mål Caspase Inhibitors
Molekylær formel C26H27F4N3O7
Renhed 0.98
Produkttitel
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