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Invitrogen™ Human EIF2AK2 (PKR), GST Tag Recombinant Protein

Artikelnummer. p-7181058
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Mængde:
10 μg
Pakningsstørrelse:
Hver
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Artikelnummer. 10022913

Brand: Invitrogen™ PV4821

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic.

EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection. PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & malignancy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P19525
Koncentration See Label
Til brug med (applikation) Kinase Assay
Formulering 50mM tris with 2mM DTT, 50% glycerol, 0.5mM EDTA, 150mM NaCl, 0.02% Triton X-100 and no preservative; pH 7.5
Gen-id (Entrez) 5610
Molekylvægt (g/mol) 62.2 kDa
Navn Human EIF2AK2 (PKR), GST Tag
pH-område 7.5
Oprensningsmetode Purified
Mængde 10 μg
Opbevaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias 2310047A08Rik; 4732414G15Rik; AI467567; AI747578; double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF2a Kinase; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2; eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; PPP1R83; Prkr; protein kinase R; protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; serine/threonine-protein kinase TIK; T-cell viral integration site; Tik; Tyrosine-protein kinase EIF2AK2
Fælles navn PKR
Gen symbol EIF2AK2
KinaseFamily PEK Kinase Family
Protein længde 252-551
Produkttype Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Protein tag GST-tag
Sekvens 252-551
Indhold og opbevaring -80°C, Avoid Freeze/Thaw Cycles
Assay Entry Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group Ser⁄Thr Kinases: Other
Forsendelsestilstand Dry Ice
Systemkompatibilitet LanthaScreen™ Antibody, LanthaScreen™ Substrate
Målindgang EIF2AK2
Target Gene eukaryotic translation initiation factor 2-alpha kinase 2
Udtrykssystem Insect cells
Protein familie Kinases & Inhibitors
Protein form Recombinant, Catalytic
Form Liquid
Protein undertype Serine/Threonine Kinases
Forskningskategori Signal Transduction
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