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Invitrogen™ Human EGFR (ErbB1), GST Tag Recombinant Protein

Artikelnummer. 11593597
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Mængde:
10 μg
100 μg
Pakningsstørrelse:
100µg
10µg
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Artikelnummer. 11593597

Brand: Invitrogen™ PV3872

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Catalytic Domain, Cytoplasmic.

EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P00533
Koncentration See Label
Til brug med (applikation) Kinase Assay
Formulering 50mM tris HCl with 0.02% Triton X-100, 50% glycerol, 2mM DTT, 150mM NaCl, 0.5mM EDTA and no preservative; pH 7.5
Gen-id (Entrez) 1956
Molekylvægt (g/mol) 90.5 kDa
Navn Human EGFR (ErbB1), GST Tag
pH-område 7.5
Oprensningsmetode Purified
Mængde 10 μg
Opbevaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias 2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Fælles navn EGFR
Gen symbol EGFR
KinaseFamily EGF Receptor (ErbB) Kinase Family
Protein længde 668-1210
Produkttype Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Protein tag GST-tag
Sekvens 668-1210
Indhold og opbevaring -80°C, Avoid Freeze/Thaw Cycles
Assay Entry Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity, Biochemical binding/kinetic
Kinase Group Tyrosine Kinases
Forsendelsestilstand Dry Ice
Systemkompatibilitet LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
Målindgang EGFR
Target Gene Epidermal growth factor receptor
Udtrykssystem Insect cells
Protein familie Kinases & Inhibitors
Protein form Recombinant, Catalytic Domain, Cytoplasmic
Form Liquid
Protein undertype Receptor Tyrosine Kinases
Forskningskategori Oncology, Signal Transduction
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