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Tocris Bioscience™ dTAGV-1
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Artikelnummer. 18707736
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5 mg
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18707736 5 mg
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Artikelnummer. 18707736 Leverandør Tocris Bioscience™ Leverandørnr. 6914/5

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Beskrivelse

Potent and selective degrader of mutant FKBP12F36V fusion proteins

dTAGV-1 is a degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a von Hippel-Lindau (VHL)-binding ligand. Induces potent and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo. Selectively degrades FKBP12F36V-EWS/FLI fusion proteins and inhibits cell proliferation in FKBP12F36V-EWS/FLI-expressing Ewing sarcoma cells. Hydrochloride salt (Cat.No. 7374) available; suitable for in vivo use. Negative control dTAGV-1-NEG (Cat. No. 6915) also available. FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in. Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R&D Systems . Email TPD@bio-techne.com to enquire. Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.
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Tekniske data

Kemisk navn eller materiale (R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-((-1-((2 S,4 R)-4-hydroxy-2-((-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl -1-(-2-(3,4,5-trimethoxyph)
Mængde 5 mg
Mål TAG Degradation Platforms
Molekylær formel C68H90N6O14S CF3CO2H
Renhed 0.98
Produkttitel
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