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Invitrogen™ Human DR5 Synthetic Peptide

Synthetic Peptide

Brand:  Invitrogen™ PEP0021

Additional Details : Weight : 0.01000kg

Product Code. 15236249

  • 1004.00 DKK / 50µg
Estimated Shipment: 11-04-2024
to see stock.

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Description

Description

DR5 Synthetic Peptide, PEP-0021, from Invitrogen.

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome. This peptide corresponds to 20 amino acids near the carboxy terminus of human DR5.PEP-0021 can be used as a blocking peptide with polyclonal antibody PA5-19895.
Specifications

Specifications

8795
purified
Human DR5
-20°C
Liquid
Blocking Assay, Control
No
Peptide
RUO - research use only
Human
O14763
200 μg/mL
Synthetic Peptide
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
TNFRSF10B
0.02% sodium azide
50 μg
PBS
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