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STEMCELL Technologies Doxycycline (Hyclate)

Artikelnummer. 17100122
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17100122 1 g
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Artikelnummer. 17100122 Leverandør STEMCELL Technologies Leverandørnr. 72742

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Beskrivelse

Antibiotic; Used in Tet-inducible gene expression systems

  • Doxycycline is a tetracycline-like antibiotic (Hicks et al.; Nau et al.; Solís García del Pozo & Solera; Steinhardt et al.) In genetic engineering, doxycycline is used as the regulator for inducible gene expression systems, whereby expression depends on either the presence (Tet-On) or absence (Tet-Off ) of doxycycline
  • Also, doxycycline inhibits certain matrix metalloproteinases (MMP), such as MMP-8 (Ki = 36 μM; Griffin et al.; Smith et al.) It only poorly inhibits MMP-1 and MMP-13 (Ki > 100 μM; Smith et al.) This product is supplied as the hyclate salt of the molecule
  • Used as the regulator for inducible gene expression in lentiviral infection and transgenic mouse models using the Tet-On or Tet-Off systems (Brambrink et al.; Carey et al.; Haenebalcke et al.; Hanna et al.; Hockemeyer et al.; Maherali et al.; Markoulaki et al.; Stadtfeld et al. 2008, 2010; Wernig et al.)

Tekniske data

CAS 24390-14-5
Synonym WC 2031
Mængde 1 g
Molekylær formel 2[C22H24N2O8] · 2HCl · H2O · C2H6O
Renhed ≥98%
Produkttitel
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