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Doxorubicin hydrochloride, Thermo Scientific™
Doxorubicin hydrochloride, CAS # 25316-40-9, is the hydrochloride salt of doxorubicin, isolated from the bacterium Streptomyces peucetius, and is considered to be an anthracycline antibiotic with antineoplastic activity.
Brand: Thermo Scientific Alfa Aesar J64000.MA
1253.75 DKK valid until 2026-07-03
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| Mængde | 10mg |
|---|
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Descrizione
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
- Doxorubicin hydrochloride, isolated from the bacterium Streptomyces peucetius, is an anthracycline antibiotic with antineoplastic activity and is related to daunorubicin
- It can intercalate between base pairs in the DNA helix preventing DNA replication
- It also inhibits the nucleic acid synthesis and can induce apoptosis
- It can inhibit DNA topoisomerase II, resulting in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication, and prevents nucleotide strand ligation after double-strand breakage
- Doxorubicin hydrochloride forms oxygen free radicals that result in cytotoxicity and lead to the lipid peroxidation of cell membrane lipids
Application
- This compound displays a fluorescent property allowing the measurement of drug efflux pump activity and examining the role of subcellular organelles (Golgi complex and lysosome) in the sequestration of drugs
- It has been used in cell viability assays
- It is used as a drug in polymeric PLGA-based microparticulate drug delivery and to develop in vitro doxorubicin-resistant HepG2 cells (HepG2-DR) and K562 cells (K562-DR)
- It is a substrate of the MRP1 transporter
Identificatori chimici
| 25316-40-9 | |
| 579.98 | |
| MWWSFMDVAYGXBV-FGBJBKNOSA-N | |
| 129626538 | |
| [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O |
| C27H30ClNO11 | |
| MFCD00077757,MFCD00077757,MFCD00941448 | |
| doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs | |
| hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride |
Specifica
| Doxorubicin hydrochloride | |
| C27H30ClNO11 | |
| 10mg | |
| 14,3439 | |
| Soluble in water. | |
| [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O | |
| 579.98 | |
| 579.99 |
| 25316-40-9 | |
| MFCD00077757,MFCD00077757,MFCD00941448 | |
| 4229251 | |
| doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs | |
| MWWSFMDVAYGXBV-FGBJBKNOSA-N | |
| hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride | |
| 129626538 |
Sicurezza e movimentazione
Identificativo prodotto
Avvertenza
Categoria di pericolo
Indicazioni di pericolo
Consigli di prudenza
Informazioni supplementari
- Doxorubicin hydrochloride
Avvertenza
- Fare
Categoria di pericolo
- Akut toksicitet Kategori 4
- Alvorlige øjenskader/øjenirritation Kategori 1
- Kimcellemutaqenicitet Kategori 1A
- Reproduktionstoksicitet Kategori 2
- Hudætsning/hudirritation Kategori 2
- Specifik målorgantoksicitet - enkelt eksponering Kategori 2
Indicazioni di pericolo
- H302-Farlig ved indtagelse.
- H315-Forårsager hudirritation.
- H318-Forårsager alvorlig øjenskade.
- H335-Kan forårsage irritation af luftvejene.
- H340-Kan forårsage genetiske defekter.
- H361fd-Mistænkes for at skade forplantningsevnen. Mistænkes for at skade det ufødte barn.
Consigli di prudenza
- P280-Bær beskyttelseshandsker/beskyttelsestøj/øjenbeskyttelse/ ansigtsbeskyttelse.
- P301+P330+P331-I TILFÆLDE AF INDTAGELSE: Skyl munden. Fremkald IKKE opkastning.
- P302+P352-VED KONTAKT MED HUDEN: Vask med rigeligt vand/.
- P304+P340-VED INDÅNDING: Flyt personen til et sted med frisk luft og sørg for, at vejrtrækningen lettes.
- P305+P351+P338-VED KONTAKT MED ØJNENE: Skyl forsigtigt med vand i flere minutter. Fjern eventuelle kontaktlinser, hvis dette kan gøres let. Fortsæt skylning.
- P310-Ring omgående til en GIFTINFORMATION/læge/.
- P332+P313-Ved hudirritation: Søg lægehjælp.
Informazioni supplementari
- MIXTURE LIST-Contain: Doxorubicin hydrochloride
Titolo del prodotto
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