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Tocris Bioscience™ Dorsomorphin dihydrochloride
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Artikelnummer. 18054882
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10 mg
50 mg
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Artikelnummer. Mængde
18054882 10 mg
18055202 50 mg
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Artikelnummer. 18054882 Leverandør Tocris Bioscience™ Leverandørnr. 3093/10

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Beskrivelse

Potent AMPK inhibitor

Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and Metformin (Cat. No. 2864). Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 1219168-18-9
Molekylær formel C24H27Cl2N5O

Tekniske data

Kemisk navn eller materiale Dorsomorphin dihydrochloride
Mængde 10 mg
Formel vægt 472.41
Renhed >98%
Molekylvægt (g/mol) 472.414
Produkttitel
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