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STEMCELL Technologies Dorsomorphin

Artikelnummer. 17160022
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50 mg
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Artikelnummer. Mængde
17160022 10 mg
17119971 50 mg
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Artikelnummer. 17160022 Leverandør STEMCELL Technologies Leverandørnr. 72102

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Beskrivelse

BMP and AMPK pathway inhibitor; Inhibits ALK2, ALK3, ALK6, and AMPK

  • Dorsomorphin inhibits the bone morphogenetic protein (BMP) pathway by targeting the type I BMP receptors activin receptor-like kinase (ALK) 2, ALK3, and ALK6
  • It is also a potent inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM) but does not significantly inhibit structurally related kinases such as ZAPK, SYK, PKCθ, PKA, or JAK3 (Bain et al.), Yu et al.)
  • Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Morizane et al.), Zhou et al.)
  • Promotes differentiation of cardiomyocytes from mouse and human pluripotent stem cells (Hao et al.), Kattman et al.)
  • Promotes differentiation of adipocytes and suppresses osteogenic differentiation of osteoblasts from human mesenchymal cells (Kim et al.)

Tekniske data

CAS 866405-64-3
Synonym Compound C
Mængde 10 mg
Molekylær formel C24H25N5O
Renhed ≥98%
Produkttitel
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