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Dolutegravir, MedChemExpress

Artikelnummer. 16491066
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Artikelnummer. Mængde
16491066 200 mg
16481656 500 mg
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16438277 5 mg
16436126 100 mg
16421747 50 mg
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Artikelnummer. 16491066 Leverandør Medchem Express Leverandørnr. HY13238
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Beskrivelse

MedChemExpress Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).

Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).

Tekniske data

Kemisk navn eller materiale Dolutegravir
Fysisk form Solid
CAS 1051375-16-6
Farve White
Mængde 200 mg
Renhedsgrad noter Research
Molekylær formel C20H19F2N3O5
Til brug med (applikation) COVID-19-anti-virus
Synonym S/GSK1349572
Opløselighedsinformation DMSO : 10 mg/mL (23.84 mM; Need ultrasonic and warming)
SMIL FC1=CC(F)=C(C=C1)CNC(C2=CN(C3=C(C2=O)O)C[C@@]([H])(N4C3=O)OCC[C@H]4C)=O
Molekylvægt (g/mol) 419.38
Formel vægt 419.38
Procent renhed 98.76%
Grad Research
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Research purposes only

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