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Invitrogen™ DOK1 Recombinant Rabbit Monoclonal Antibody (JE54-52)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA536191
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Beskrivelse
DOK1 Recombinant Monoclonal Antibody for Western Blot
DOK1 (P62dok, Docking protein 1) is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. DOK1 is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK1 forms a complex with ras GTPase-activating protein. Phosphorylation on tyrosine residues by the insulin receptor kinase results in the negative regulation of the insulin signaling pathway. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.
Tekniske data
| DOK1 | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4 | |
| Q4QQV2, Q99704 | |
| DOK1 | |
| Recombinant protein within Human DOK1 aa 360-481. | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
| Western Blot | |
| JE54-52 | |
| Unconjugated | |
| DOK1 | |
| AW557123; Docking protein 1; docking protein 1, 62kDa (downstream of tyrosine kinase 1); Dok; DOK 1; DOK1; Dok-1; Downstream of tyrosine kinase 1; downstream of tyrosine kinase-1; MGC117395; MGC138860; p240; p62 dok; p62(dok); p62DOK; pp62; TLP1; TP1; TROVE domain family; TROVE1; VAULT2 | |
| Rabbit | |
| Protein A | |
| RUO | |
| 1796, 312477 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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