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Invitrogen™ Human DNA-PK Native Protein

Artikelnummer. 15378517
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Mængde:
1 mg
10 μg
100 μg
Pakningsstørrelse:
100µg
10µg
Hver
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Artikelnummer. Mængde unitSize
15378517 1 mg Hver
15117975 100 μg 100µg
15428803 10 μg 10µg
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Artikelnummer. 15378517 Leverandør Invitrogen™ Leverandørnr. PV5865

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Beskrivelse

Native Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Native human protein purified from MOLT-4 cells. No special measures were taken to activate this kinase. Protein Form: Full Length.

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P78527
Koncentration Conc. Not Determined
Til brug med (applikation) Kinase Assay
Formulering 25mM HEPES with 10mM MgCl2, 50mM KCl, 1mM DTT, 0.2mM EDTA, 10% glycerol and no preservative; pH 7.5
Gen-id (Entrez) 5591
Molekylvægt (g/mol) 600 kDa
Navn Human DNA-PK
pH-område 7.5
Mængde 1 mg
Opbevaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
Fælles navn DNA-PK
Gen symbol PRKDC
KinaseFamily PIKK Kinase Family
Produkttype Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Native
Protein tag Untagged
Sekvens Full length
Indhold og opbevaring Kinase proteins are shipped on dry ice and should be stored at -80°C.
Kinase Group Ser⁄Thr Kinases: Atypical
Forsendelsestilstand Dry Ice
Udtrykssystem Baculovirus
Protein familie Kinases & Inhibitors
Protein form Full Length
Form Liquid
Protein undertype Serine/Threonine Kinases, Atypical
Forskningskategori Drug Discovery: Signal Transduction
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