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Invitrogen™ DNA ligase IV Polyclonal Antibody

Artikelnummer. 13403027
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Mængde:
100 μL
Pakningsstørrelse:
100µL
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13403027 100 μL 100µL
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Artikelnummer. 13403027 Leverandør Invitrogen™ Leverandørnr. PA528903

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Beskrivelse

Rabbit Polyclonal Antibody

Recommended positive controls: U87-MG, mouse brain, rat brain. Predicted reactivity: Mouse (82%), Rat (81%), Sheep (83%), Bovine (86%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
TRUSTED_SUSTAINABILITY

Tekniske data

Antigen DNA ligase IV
Applikationer Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Klassifikation Polyclonal
Koncentration 1 mg/mL
Konjugeret Unconjugated
Formulering 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene LIG4
Genadgangsnr. P49917, Q8BTF7
Gene Alias 5830471N16Rik; DNA joinase; DNA ligase (ATP) 4; DNA ligase 4; DNA ligase IV; DNA repair enzyme; Lig4; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase; tiny
Gensymboler LIG4
Værtsarter Rabbit
Immunogen Recombinant protein encompassing a sequence within the C-terminus region of human DNA ligase IV. The exact sequence is proprietary.
Oprensningsmetode Antigen affinity chromatography
Mængde 100 μL
Regulatorisk status RUO
Primær eller sekundær Primary
Gen-id (Entrez) 290907, 319583, 3981
Målarter Human, Mouse, Rat
Indhold og opbevaring Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Produkttype Antibody
Form Liquid
Isotype IgG
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