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Invitrogen™ DNA ligase IV Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA528903

Produktkode 13403027

  • 3955.00 DKK / 100µL

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Beskrivelse

Beskrivelse

Recommended positive controls: U87-MG, mouse brain, rat brain. Predicted reactivity: Mouse (82%), Rat (81%), Sheep (83%), Bovine (86%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
TRUSTED_SUSTAINABILITY
Tekniske data

Tekniske data

DNA ligase IV
Polyclonal
Unconjugated
LIG4
5830471N16Rik; DNA joinase; DNA ligase (ATP) 4; DNA ligase 4; DNA ligase IV; DNA repair enzyme; Lig4; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase; tiny
Rabbit
Antigen affinity chromatography
RUO
290907, 319583, 3981
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
P49917, Q8BTF7
LIG4
Recombinant protein encompassing a sequence within the C-terminus region of human DNA ligase IV. The exact sequence is proprietary.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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