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Tocris Bioscience™ DMH-1
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Artikelnummer. 18005362
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50 mg
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Artikelnummer. Mængde
18005362 10 mg
18065942 50 mg
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Artikelnummer. 18005362 Leverandør Tocris Bioscience™ Leverandørnr. 4126/10

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2371.94 DKK valid until 2026-06-30
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Beskrivelse

Selective ALK2 inhibitor

DMH-1 is a selective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC50 = 108 nM or 12.6 nM in in vitro kinase assays). DMH-1 exhibits 6- and 19-fold selectivity for ALK-2 over ALK-1 and ALK-3, respectively, and no significant inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. DMH-1 blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614). DMH-1 suppresses lung cancer cell proliferation, migration, invasion in vitro and reduces tumor growth in a mouse lung cancer xenograft model. DMH-1 inhibits cellular autophagy responses. DMH-1 induces intestinal differentiation in human intestinal organoids (hIOs) derived from human pluripotent stems cells (hPSCs).
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Kemiske identifikatorer

CAS 1206711-16-1
Molekylær formel C24H20N4O

Tekniske data

Kemisk navn eller materiale DMH-1
Mængde 10 mg
Formel vægt 380.44
Renhed >98%
Molekylvægt (g/mol) 380.45
Produkttitel
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