Invitrogen™ DLK1 Monoclonal Antibody (3A10)

Beskrivelse

MA5-15915 targets DLK1 in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human samples. The MA5-15915 immunogen is purified recombinant fragment of human DLK1 expressed in E. Coli. . MA5-15915 detects DLK1 which has a predicted molecular weight of approximately 41kDa.

The Delta-like 1 homolog (DLK1) is a transmembrane protein containing six epidermal growth factor repeats. It is involved in the differentiation of several cell types, including adipocytes and is also thought to be a tumor suppressor. The DLK1 gene is one of several imprinted genes located in a region on chromosome 14q32; certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). DLK1 is expressed from the paternal allele; a polymorphism within this gene has been associated with child and adolescent obesity.