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DLK-IN-1, MedChemExpress

Artikelnummer. 16487557
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Artikelnummer. 16487557 Leverandør Medchem Express Leverandørnr. HY114331

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Beskrivelse

MedChemExpress DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.

DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.

Tekniske data

Kemisk navn eller materiale DLK-IN-1
CAS 1620574-24-4
Farve White
Renhedsgrad noter Research
Molekylær formel C20H24F3N5O2
Mængde 5 mg
Opløselighedsinformation DMSO : 62.5 mg/mL (147.60 mM; Need ultrasonic)
SMIL CC(N1C([C@@H]2[C@]3([H])[C@@]2([H])CN(C4COC4)C3)=CC(C5=CN=C(N)C(OC(F)(F)F)=C5)=N1)C
Molekylvægt (g/mol) 423.43
Formel vægt 423.43
Procent renhed 99.41%
Grad Research
Fysisk form Solid
Til brug med (applikation) Neuroscience-Neurodegeneration
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Research purposes only

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