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Tocris Bioscience™ DD 03-171
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Artikelnummer. 18756836
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5 mg
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18756836 5 mg
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Artikelnummer. 18756836 Leverandør Tocris Bioscience™ Leverandørnr. 7160/5

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Beskrivelse

Potent and selective BTK Degrader (PROTAC™)

DD 03-171 is a potent and selective BTK Degrader (PROTAC™) (IC50 = 5.1 nM); degrades BTK in a proteasome- and CRBN-dependent manner. Suppresses BTK signaling and proliferation in mantle cell lymphoma (MCL) cells by degrading BTK, IKFZ1, and IKFZ3 (3 validated targets in B-cell malignancies). Also degrades Ibrutinib (Cat. No. 6813) -resistant C481S-BTK mutant cancer cells. Exhibits no binding against a panel of 468 kinases at 1 μM. Reduces tumor burden and extends survival in lymphoma patient-derived xenograft models. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
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Tekniske data

Kemisk navn eller materiale 4-(1,1-Dimethylethyl)-N-[3-[6-[[4-[[4-[6-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-4-yl]amino]acetyl]amino]hexyl]-1-piperazinyl]carbonyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]benzamide
CAS 2366132-45-6
Mængde 5 mg
Mål Active Degraders
Molekylær formel C55H62N10O8
Renhed 0.98
Produkttitel
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