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Tocris Bioscience™ DCLK1-IN-1
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Artikelnummer. 18706856
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Mængde:
5 mg
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18706856 5 mg
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Artikelnummer. 18706856 Leverandør Tocris Bioscience™ Leverandørnr. 7285/5

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Beskrivelse

Potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor; orally bioavailable

DCLK1-IN-1 is a potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor (IC50 values are DCLK1 =9.5 and 57.2 nM and DCLK2 = 31 and 103 nM in binding and kinase assay, respectively). Exhibits no significant activity against ERK5, ACK, BRD4 and LRRK2. Exhibits DCLK inhibition in pancreatic ductal adenocarcinoma (PDAC) organoid models. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-5-(2,2,2-trifluoroethyl)-6 H-pyrimido[4,5-b][1,4 ]benzodiazepin-6-one
CAS 2222635-15-4
Mængde 5 mg
Mål Other Kinase Inhibitors
Molekylær formel C26H28F3N7O2
Renhed 0.98
Produkttitel
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