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Tocris Bioscience™ DBZ
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Artikelnummer. 18710688
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Mængde:
10 mg
50 mg
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Artikelnummer. Mængde
18710688 10 mg
18724957 50 mg
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Artikelnummer. 18710688 Leverandør Tocris Bioscience™ Leverandørnr. 4489/10

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Beskrivelse

γ-secretase inhibitor; inhibits Notch pathway

DBZ is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC. In an animal model of Alzheimer's disease, DBZ inhibits the cleavage of amyloid precursor protein into Aβ40. DBZ promotes cochlear supporting cell proliferation and hair cell mitotic regeneration in neonatal mice. DBZ in combination with iDOT1L enables maintenance of human na?ve-state pluripotency in non-hypoxic conditions.

DBZ synthesized to Ancillary Material Grade also available.

TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale DBZ
CAS 209984-56-5
Analyseprocentområde >98%
Mængde 10 mg
Molekylær formel C26H23F2N3O3
Formel vægt 463.48
Produkttitel
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