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Tocris Bioscience™ Dasatinib
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Artikelnummer. 18708146
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Mængde:
100 mg
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18708146 100 mg
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Artikelnummer. 18708146 Leverandør Tocris Bioscience™ Leverandørnr. 6793/100

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Beskrivelse

Highly potent pan-Src/Bcr-Abl inhibitor

Dasatinib is a highly potent pan-Src/Bcr-Abl inhibitor (Ki values are 16 and 30 pM, respectively. Inhibits Bcr-Abl, Src, Lck, Fyn, c-kit and Yes with IC50 values in the subnanomolar range. Inhibits proliferation of tumor cells in vitro and exhibits anticancer acivity in vivo in a mouse chronic myelogenous leukemia (CML) xenograft model. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 2.1and 5.5 μM, respectively). Dasatinib also enhances CD3-targeted lentiviral vector-mediated gene transfer by 3 to 10-fold.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
CAS 302962-49-8
Synonym BMS-354825
Mængde 100 mg
Molekylær formel C22H26ClN7O2S
Formel vægt 488.01
Renhed 98%
Produkttitel
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