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STEMCELL Technologies D4476

Artikelnummer. 17100312
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Mængde:
5 mg
Pakningsstørrelse:
5mg
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Artikelnummer. 17100312 Leverandør STEMCELL Technologies Leverandørnr. 74012

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Beskrivelse

Activin/NODAL/TGF-β pathway inhibitor; Inhibits CK1, ALK5 and p38 MAPK

  • D4476 is a selective, potent, and cell-permeant inhibitor of casein kinase (CK) 1 (Rena et al.) It inhibits CK1 and CK1δ from S
  • pombe (IC50 = 200 nM and 300 nM, respectively; Bain et al.; Rena et al.) It also inhibits transforming growth factor β1 (TGF-β1) type I receptor (ALK5) with IC50 = 500 nM (Rena et al.)
  • Along with forskolin (Catalog #72112) and 2-methyl-5-hydroxytryptamine, reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.)
  • Reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.)
  • Induces apoptosis of multiple myeloma cell lines (Hu et al.)
  • Exhibits anti-leukemic activity by selectively killing leukemia stem cells over normal hematopoietic stem and progenitor cells (Järås et al.)

Tekniske data

CAS 301836-43-1
Synonym Casein Kinase I Inhibitor
Mængde 5 mg
Molekylær formel C23H18N4O3
Renhed ≥98%
Produkttitel
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