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Tocris Bioscience™ Cysmethynil
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Artikelnummer. 18796696
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Mængde:
10 mg
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18796696 10 mg
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Artikelnummer. 18796696 Leverandør Tocris Bioscience™ Leverandørnr. 7337/10

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Beskrivelse

ICMT inhibitor; arrests cell-cycle at G1 phase

Cysmethynil is an isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor (IC50 = 2.4 μM). Cysmethynil reduces growth of RAS-mutant cell lines in vitro and in vivo (EC50 = 20 μM) and reduces cell viability in a variety of cell lines (IC50 = 16.8-23.3 μM). Tumor growth, mTOR signaling and cell proliferation are inhibited by cysmethynil; apoptosis is induced. Cysmethynil increases p27 and p21 proteins and arrests cell-cycle at the G1 phase.
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Tekniske data

Kemisk navn eller materiale 5-(3-Methylphenyl)-1-octyl-1 H-indole-3-acetamide
CAS 851636-83-4
Mængde 10 mg
Mål Other Transferase Inhibitors
Molekylær formel C25H32N2O
Renhed 0.98
Produkttitel
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