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STEMCELL Technologies Cyclopamine

Artikelnummer. 17120022
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5 mg
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Artikelnummer. Mængde
17120022 1 mg
17130022 5 mg
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Artikelnummer. 17120022 Leverandør STEMCELL Technologies Leverandørnr. 72072

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Beskrivelse

Hedgehog pathway inhibitor; Inhibits Smoothened (SMO)

  • Cyclopamine is a steroid alkaloid that inhibits the Hedgehog pathway at the point of the pathway activator Smoothened
  • Cyclopamine binds to the heptahelical bundle of Smoothened, a G protein-coupled receptor, and prevents it from signaling further downstream (Chen et al.)
  • Reduces proliferation of rat neural progenitor cells and mouse neurospheres (Lai et al.; Palma and Ruiz i Altaba)
  • Reduces proliferation of mouse mammospheres (Liu et al.)
  • Promotes differentiation of pancreatic cells from human embryonic stem cells (D'Amour et al.)
  • Inhibits the growth of human and mouse medulloblastoma cells, and human glioblastoma cells (Bar et al.), Berman et al.)

Tekniske data

CAS 4449-51-8
Synonym 11-Deoxojervine; Jervine
Mængde 1 mg
Molekylær formel C27H41NO2
Renhed ≥95%
Produkttitel
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