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Tocris BioScience™ CX-4945

Artikelnummer. 31900358
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10 mg
50 mg
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Artikelnummer. Mængde
31900358 10 mg
31900356 50 mg
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Artikelnummer. 31900358 Leverandør Tocris BioScience™ Leverandørnr. 8993/10

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Beskrivelse

Potent and selective CK2α and CK2α' inhibitor. Also blocks CK2-dependent HIF-1α transcription, causes cell-cycle arrest, induces apoptosis in cancer cells and induces stem cell reprogramming

CX-4945 (Silmitasertib) is a potent and selective inhibitor of protein kinase CK2α and CK2α' (IC50 = 1 nM). It shows greater than 500-fold selectivity for CK2 over a panel of > 200 kinases.

CX-4945 can be used, in combination with other small molecules, in fast chemical reprogramming protocols for the induction of human somatic cells and highly efficient generation of pluripotent stem cells (hCiPS) in a minimum of 16 days with robust repeatability and reliability.

CX-4945 has antiproliferative effects in vitro as it attenuates PI3K/Akt signalling, causes cell-cycle arrest and selectively induces apoptosis in cancer cells. In models of angiogenesis, CX-4945 inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.

In vivo, CX-4945 displays robust antitumor activity with concomitant reduction of the mechanism-based biomarker phospho-p21 (T145) (murine xenograft model). CX-4945 is orally bioavailable.

TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale Sodium 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylate
CAS 1309357-15-0
Mængde 10 mg
Mål Casein Kinase 2 Inhibitors
Molekylær formel C19H11ClN3O2Na
Renhed 98%
Produkttitel
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