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Tocris Bioscience™ CTPI 2
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Artikelnummer. 30000417
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50 mg
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Artikelnummer. Mængde
30000417 50 mg
30000413 10 mg
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Artikelnummer. 30000417 Leverandør Tocris Bioscience™ Leverandørnr. 7794/50

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Beskrivelse

Selective mitochondrial citrate transporter (SLC25A1) inhibitor

CTPI 2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor with a KD of 3.5 μM. CTPI 2 inhibits the proliferation of H1299 cells in a SLC25A1-dependent manner. It also re-sensitizes T1, T2, and T4 cells to Cisplatin (Cat. No. 2251). CTPI 2 inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC). In high-fat diet fed mice CTPI 2 regulates glycolysis, prevents steatohepatitis and normalizes glucose tolerance and insulin sensitivity. CTPI 2 influences the inflammatory pathway by inhibiting IL-6 and TNFα production and M1 macrophage polarization.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 2-[[(4-Chloro-3-nitrophenyl)sulfonyl]amino]benzoic acid
CAS 68003-38-3
Mængde 50 mg
Mål Other Ion Pump/Transporter Inhibitors
Molekylær formel C13H9ClN2O6S
Renhed 98%
Produkttitel
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