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Invitrogen™ Human CSNK1E (CK1 epsilon) [R178C], GST Tag Recombinant Protein

Artikelnummer. 17138835
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Mængde:
1 mg
10 μg
100 μg
Pakningsstørrelse:
100µg
10µg
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Artikelnummer. 17138835

Brand: Invitrogen™ A33721

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This CSNK1E (CK1 epsilon) R178C recombinant human protein (full length) was expressed in insect cells. CSNK1E (CK1 epsilon) R178C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the Z'-LYTE™ assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Full Length, Recombinant, Active The gene accession number for CSNK1E (CK1 epsilon) [R178C] is NP_001885.1.

CSNK1E serine/threonine kinase is a member of the CK1 family which plays an important role in diverse cell processes, including DNA replication and repair. CSNK1E is a regulator of Yes-associated protein (YAP) transcription coactivator, which is a key regulator of organ size and a candidate human oncogene. CSNK1E is activated by CCK2R and then phosphorylates PKD2 at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells. CSNK1E can phosphorylate topoisomerase (topo) II alpha at serine-1106 and this regulates the enzyme activity and sensitivity to topo II-targeted drugs.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P49674
Koncentration See Label
Til brug med (applikation) Kinase Assay
Formulering 50mM tris HCl with 25% glycerol, 0.1mM PMSF, 0.25mM DTT, 0.1mM EDTA, 150mM NaCl, 10mM glutathione and no preservative; pH 7.5
Gen-id (Entrez) 1454
Molekylvægt (g/mol) 73.6 kDa
Navn Human CSNK1E (CK1 epsilon) [R178C], GST Tag
pH-område 7.5
Oprensningsmetode Purified
Mængde 1 mg
Opbevaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias CK1
Fælles navn CK1 epsilon (R178C Mutant)
Gen symbol CSNK1E
KinaseFamily CK1 Kinase Family
Produkttype Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Protein tag GST-tag
Sekvens Full length
Indhold og opbevaring -80°C, Avoid Freeze/Thaw Cycles
Forsendelsestilstand Dry Ice
Udtrykssystem Insect cells
Protein form Full Length, Recombinant, Active
Form Liquid
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