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COTI-2, MedChemExpress

Artikelnummer. 16473706
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Artikelnummer. Mængde
16473706 25 mg
16460418 5 mg
16457746 100 mg
16453887 50 mg
16427958 10 mg
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Artikelnummer. 16473706 Leverandør Medchem Express Leverandørnr. HY19896

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Beskrivelse

MedChemExpress COTI-2, an anti-cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI-2 acts both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. COTI-2 induces apoptosis in multiple human tumor cell lines. COTI-2 exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms. COTI-2 converts mutant p53 to wild-type conformation.

COTI-2, an anti-cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI-2 acts both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. COTI-2 induces apoptosis in multiple human tumor cell lines. COTI-2 exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms. COTI-2 converts mutant p53 to wild-type conformation.

Tekniske data

Kemisk navn eller materiale COTI-2
CAS 1039455-84-9
Farve Yellow
Renhedsgrad noter Research
Molekylær formel C19H22N6S
Mængde 25 mg
Opløselighedsinformation DMSO : 5 mg/mL (13.64 mM; Need ultrasonic)
SMIL S=C(N1CCN(C2=NC=CC=C2)CC1)N/N=C3CCCC4=C\3N=CC=C4
Molekylvægt (g/mol) 366.48
Formel vægt 366.48
Procent renhed 98.48%
Grad Research
Fysisk form Powder
Til brug med (applikation) Cancer-programmed cell death
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Research purposes only

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