Cortisol Monoclonal Antibody (F4P1A3), Invitrogen™

Description

MIC0201 targets Cortisol in ELISA, IP, and RIA applications and shows reactivity with Chemical samples. The MIC0201 immunogen is cortisol-3-CMO-BSA. MIC0201 was formerly sold as a Seradyn product.

Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.