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Invitrogen™ Claudin 1 Monoclonal Antibody (2H10D10)

Beskrivelse
Reactivity has been confirmed with human Caco-2 and canine MDCK cell lysates, mouse kidney and intestinal lysates, frozen mouse intestine (jejunum) tissue, and rat kidney homogenates. This antibody is specific for the C-terminal region of the claudin-1 protein. On western blots, it identifies the target band at ~22 kDa.
Claudin-1 is a member of the transmembrane protein family claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian tube, liver, pancreas, prostate, and skin.
Tekniske data
Tekniske data
| Antigen | Claudin 1 |
| Applikationer | ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry |
| Klassifikation | Monoclonal |
| Klon | 2H10D10 |
| Koncentration | 0.5 mg/mL |
| Konjugeret | Unconjugated |
| Formulering | PBS with 0.1% sodium azide; pH 7.4 |
| Gene | CLDN1 |
| Genadgangsnr. | O88551, O95832, P56745 |
| Gene Alias | AI596271; claudin 1; claudin-1; CLD1; CLDN1; hypothetical protein; ILVASC; SEMP1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1; tight junction protein; UNQ481/PRO944 |
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